super_si

Is this weeks drug i need info on

Getting bad joint pains this week my new injury hehehe.

frieds said its growing pains and id might aswell get used to it and reccomended the above product.

Any info gratly anticipated.

Si

Redkop

I know it works very well on dogs, so I tried some and tbh I didn't notice any difference

super_si

Just noticed my Dads on them for his knee's.
Cant be illegal then

Si

RobinSherwood

Si,

We looked into this when it first came on the market and considered how in injectable form it may help some of our patients with arthritis who were slow to respond to the other treatments we use. We also discussed its effectiveness with a friend/colleague who is an orthopaedic surgeon. There is nothing wrong with it, but we found that it didn't help enough people to be worthwhile and the people that it did help responded to other treatment and would most likely have got better anyway. Ultimately it is not as effective in promoting repair in joints as another medcine we use (and are trying to do a clinical trial with). In summary it works for some people but nothing to get excited about

Regards

Robin

SPEN555

Si,

If you look at the number of tablets you need to take (per instructions on the tub) it works out at costing something ridiculous like £30 per month!

Damian.

Richard Work

Interesting ....been taking a product that contains this stuff for a while now, can't say that I've noticed any joint benefits, but then I don't have any joint issues and haven't been taking it in doses for that purpose, didn't know it had that benefit. The combined benefits of some of these sugars is amazing though - haven't been sick in over a year now.

Some more info from here:
http://www.glycoscience.com/glycosci...FILENAME=H379A



Glucosamine is an amino sugar that is found in almost all human tissues.4 Approximately twenty-six percent of orally consumed glucosamine is incorporated into plasma proteins. Unbound glucosamine is concentrated in articular cartilage. The fraction not metabolized or incorporated into plasma proteins is excreted mainly in urine.13 Cartilage is composed of glycosaminoglycans (proteoglycans, which contain glucosamine, galactosamine, and mannose). Patients with osteoarthritis (OA) suffer from progressive degeneration of cartilage proteoglycans. When compared with healthy control subjects, individuals with rheumatoid arthritis and osteoarthritis excrete significantly more glucosamine, galactosamine, and mannose.25 Moreover, the severity of the pathology of osteoarthritis is correlated inversely with decreased concentration of glucosamine in femur cartilage.26 In addition to the traditional view that glucosamine promotes synthesis of cartilage proteoglycans, glucosamine may also stimulate synovial production of hyaluronic acid, which is primarily responsible for the lubricating and shock-absorbing properties of synovial fluid.27 In an in vitro study, glucosamine hydrochloride inhibited the degradation of cartilage.28 In a recent animal study, oral glucosamine was shown to be bioavailable to chondrocytes in joint cartilage, which suggests that glucosamine could be available for proteoglycan biosynthesis.29

In the U.S., glucosamine has gained popularity as a dietary supplement, where it is frequently used with chondroitin. While many studies have investigated the effects of glucosamine, chondroitin has received less attention.4 Ninety percent of dietary glucosamine sulfate is absorbed, in contrast to chondroitin sulfate, which is a large molecule and is poorly absorbed. When compared with glucosamine sulfate, glucosamine hydrochloride is more pure and more bio-reactive; smaller doses are thus needed for therapeutic efficacy.4

There is a growing body of evidence suggesting that glucosamine may be effective in treating the symptoms of pain and restricted movement associated with OA,7 ,12 ,16 ,18 ,20 ,23 in some instances as equally effective as nonsteroidal anti-inflammatory drugs (NSAIDs).4 ,6 ,17 In a 3-year randomized, double-blind placebo controlled trial, patients taking 1,500 mg glucosamine sulfate experienced reduced joint degeneration and improved symptoms when compared with control patients.19 Other studies have not reported definitive benefits for OA patients.13 ,20 ,22 Many investigators have concluded that improvements in study design and data analysis are needed before beneficial effects can be absolutely validated.4 ,8 ,9 ,11 ,13 ,17 ,20 ,30 ,31 ,32 ,33

And yet, recent reviews of all randomized controlled trials investigating the efficacy of glucosamine and OA concluded that glucosamine was effective and safe.7 ,10 Despite the preponderance of evidence supporting some level of benefit for patients, the American College of Rheumatology Subcommittee on Osteoarthritis has yet to recommend that physicians use glucosamine as a treatment for OA. A large scale research study launched by the National Institute of Arthritis and Musculoskeletal and Skin Diseases in collaboration with the National Center for Complementary and Alternative Medicine, expected to be complete in 2004, will hopefully finally resolve this question for physicians and their patients.9 ,31

Other studies suggest the promise of dietary glucosamine in encouraging healing of wounds and gastrointestinal disorders.23 It has been speculated that glucosamine may also retard atherogenesis by promoting vascular endothelial cell production of heparan sulfate proteoglycans.24

SCOSaltire

i have problems with me neck.

i find that if i get really sore - then this stuff helps a bit.
either that or it may have been getting better anyway.

RobinSherwood

IMHO it would may help the symptoms of your neck pain but would do nothing for the underlying problem.

Robin

Richard Work

What do you do Robin - are you a doctor?

SCOSaltire

aye, it doesnt help the problem.. its still there

the person who manipulates me neck still hasnt got the right side of the top two vertibrae to stay in the right location

RobinSherwood

Richard,

No I am not a doctor.

But I run my old man's business and he is one of the world's top specialists on non specific backpain and joint pain. So I know about what we do indside out as one of my jobs is to talk to perspective patients on the phone. BTW we are not alternative medicine but advanced conventional medicine just so you understand the angle I am coming from.

Kind regards

Robin

Flat 4x4

I admit it - I'm a user!

I have used it for a couple of years for my knees (father had arthritis from similar age, and always my weak point from playing football) which stiffen up badly at tiems - especialy in the winter.

Don't know if its placebo effect or not, but as with many supplements, its down to the individual user's experience.

Fat Boy

I've used it for years with Chondroitin after just the 12 ops so far on my left knee (osteochondritis dissecans plus rugby, football, skiing etc - now have funky bits of carbon fibre/titanium mixed in with what's left of my knee)and I've found that it helps a little bit, but possibly that could be placebo effect as Cod liver oil seems to help the mobility of my glass knee just as much.

You have to take it for quite a while before you start to see any effects (like 3 months) and its not cheap, but I do tend to notice after a while if I stop taking it.

It allegedly helps promote the repair and/or slipperiness of the cartilage in damaged/ worn out joints. Not a body building supplement by any description as far as I'm concerned.

Dougster

Si, it is meant to be like semi synthetic running over your bones!!