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antibiotics - truth or fiction?

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Old 25 October 2002, 04:43 PM
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uncle buck
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Question

I am starting a course of said pills and a dicussion arose regarding not drinking alcohol whilst on the course because it 'stops them working'

Is this true or just an old wifes' tale?

Does anyone on here know?

Thanks,

UB.
Old 25 October 2002, 04:44 PM
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Mice_Elf
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Depends on the type of anti-biotics. Some have a reaction to ingredients in alcohol...some ingredients cancel each other out.

What are you taking, if it's not too personal a question?
Old 25 October 2002, 04:47 PM
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uncle buck
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No not personal at all. Got a nasty bug in my gut :ugh:

and have been perscribed Ciprofloxacin if that means anything.
Old 25 October 2002, 04:50 PM
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stevem2k
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Isn't that the one they give you for anthrax ??


Old 25 October 2002, 04:54 PM
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uncle buck
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Struth you're right!!

http://www.fda.gov/cder/drug/infopage/cipro/
Old 25 October 2002, 04:55 PM
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Mice_Elf
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In plain English :

Ciprofloxacin hydrochloride tablets and oral suspension are synthetic broad spectrum antimicrobial agents for oral administration. Ciprofloxacin hydrochloride, a fluoroquinolone is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluora-1, 4-dihydro-4-oxa-7-(1-piperazinyl)-3-quinolinecarboxylic acid. It is a faintly yellowish to light yellow crystalline substance with a molecular weight of 385.8. Its empirical formula is C17H18FN3O3·HCl·H2O.

Ciprofloxacin is 1-cyclopropyl-6-fluoro-1, 4-drhydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C17H18FN3O3 and its molecular weight is 331.4 It is a faintly yellowish to light yellow crystalline substance.

Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position.

Cipro film-coated tablets are available in 100-mg, 250-mg, 500-mg and 750-mg (ciprofloxacin equivalent) strengths. The inactive ingredients are starch, microcrystalline cellulose, silicon dioxide, crospovidone, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, polyethylene glycol and water.

Ciprofloxacin HCl oral suspension is available in 5% (5 g ciprofloxacin in 100 ml) and 10% (10 g ciprofloxacin in 100 ml) strengths. Ciprofloxacin HCl oral suspension is a white to slightly yellowish suspension with strawberry flavor which may contain yellow-orange droplets. It is composed of ciprofloxacin microcapsules and diluent which are mixed prior to dispensing (See PATIENT PACKAGE INSERT). The components of the suspension have the following compositions:

Microcapsules: Ciprofloxacin, polyvinylpyrrolidone, methacrylic acid copolymer, hydroxypropyl methylcellulose, magnesium stearate and Polysorbate 20.

Diluent: Medium-chain triglycerides, sucrose, lecithin, water, and strawberry flavor.

I.V.

Ciprofloxacin is a synthetic broad-spectrum antimicrobial agent for intravenous (I.V.) administration. Ciprofloxacin, a fluoroquinolone, is 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, its empirical formula is C17H18FN3O3.

Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 331.4. It is soluble in dilute (0 1N) hydrochloric acid and is practically insoluble in water and ethanol. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. Cipro I.V. solutions are available as sterile 1.0% aqueous concentrates, which are intended for dilution prior to administration, and as 0.2% ready-for-use infusion solutions in 5% Dextrose injection. All formulas contain lactic acid as a solubilizing agent and hydrochloric acid for pH adjustment. The pH range for the 1.0% aqueous concentrates in vials is 3.3 to 3.9. The pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6.

The plastic container is fabricated from a specially formulated polyvinyl chloride. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di(2-ethylhexyl) phthalate (DEHP), up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

From Here
Old 25 October 2002, 04:56 PM
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Mice_Elf
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UB - you ARE over 18, yes?

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Old 25 October 2002, 04:57 PM
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uncle buck
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sadly, yes some way....
Old 25 October 2002, 05:02 PM
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uncle buck
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otherwise I wouldn't be able to drink on them

Mice_Elf - which catagory do these come under? Drink ok or no k?
Old 25 October 2002, 05:06 PM
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Mice_Elf
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I would say "no" to alcohol whilst taking this drug....

Side effects

Nausea, diarrhea, vomiting, and abdominal pain are the most frequent side effects of ciprofloxacin. Bad taste in the mouth, restlessness, rash, sensitivity to sunlight and seizures are other possible side effects.

Dosage

Cipro comes in intravenous and pill form. Pills are taken on an empty stomach 2 hours after meals, 250-750 mg every 12 hours. If there is stomach irritation, the pill can be taken with meals. Food slows and may slightly decrease absorption. If you are taking antacids, you should take them at least 2 hours before or after the cipro. Intravenous infusion is 200-400 mg every 12 hours. Infusion takes one hour. Cipro is also given in drops into the eye to treat some eye infections. You will be given 1-2 drops 4-6 times daily until the infection is controlled. Children under 18 should not take ciprofloxacin. Safety is not established if you are breast feeding. Dosage reduction is required if your kidneys are damaged. If you have any CNS infections, cipro must be used with caution.

How long it may take to work

Variations in response depend on the state of your general health and immune system, the strain of MAC you are infected with, and the ability to tolerate a combination of drugs. The decision about what drug to take must partly be based on how sick you are and whether treatment has a chance of improving your quality of life. If you have clinical symptoms but a relatively well-functioning liver and kidneys, you will respond best to treatment. Treatment usually helps within 2 to 4 weeks. If it does work, ongoing maintenance therapy to suppress the infection is necessary. Maintenance treatment means you keep taking the drug to control an infection so that you don't become ill.

Managing side effects

Cipro may cause dizziness or lightheadedness. If you have loose or foul-smelling stools, tell your doctor as that could be a sign of another strain of MAC or a different infection. Drink a lot of high calorie fluids such as juices and nectars to prevent dehydration.
Old 25 October 2002, 05:09 PM
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uncle buck
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Unhappy

- it's not going to be a great weekend then.....
Old 25 October 2002, 05:10 PM
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Mice_Elf
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Fruit juices and squash only, I'm afraid....

Shouldn't be for too long, though - the quicker the infection clears up, the quicker you can be out glugging your way through the beer mountain.
Old 25 October 2002, 05:11 PM
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uncle buck
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true, true....

thanks for the info. (parp)
Old 25 October 2002, 05:22 PM
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DavidRB
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I've known several people not complete a course of antibiotics because they couldn't go without alcohol. Of course, they also whinge about antibiotic-resistant bugs in hospitals.
Old 25 October 2002, 05:26 PM
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uncle buck
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it's gonna be tough - especially as it's the weekend

But I certainly will finish the course though. I had to pay full whack for these little buggers [img]images/smilies/mad.gif[/img]
Old 25 October 2002, 05:28 PM
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I'll have an extra bottle of wine tonight in your honour.
Old 25 October 2002, 05:30 PM
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[img]images/smilies/mad.gif[/img]
Old 25 October 2002, 09:21 PM
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Mark Jackson
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At least you can still pop one off on antibiotics, Heliocabacter is a nasty bugger !
Old 25 October 2002, 09:54 PM
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Sounds as if it'll give you a good excuse for f*rting too:
Alcazar
Old 26 October 2002, 11:45 AM
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Ideally you should not drink alcohol with any antibiotics. However, the only antibiotic which specifically reacts with alcohol is metronidazole ( aka Flagyl). Thus in moderation you shouldn't have any problems!

NIB
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