I got a dull headache after my first week on methylated B-complex. Thought it was placebo, but it repeated soon after next dose. I stopped — headache disappeared.

I had something similar happen — a dull, lingering headache during my first week of taking a methylated B-complex. At first I brushed it off as a coincidence, but when the same headache returned shortly after the next dose, it became pretty clear the supplement wasn’t agreeing with me. Once I stopped, the headache disappeared within a day. Some people seem more sensitive to strong active forms, especially methylfolate and methyl B12. If anyone else experiences this, checking the dose or switching brands like https://primevitalitydirect.com might help.

On the flip side, many people don’t get any adverse effects. I took a standard B-complex and felt nothing negative — only slight mood lift. So maybe it depends on personal sensitivity or dosage.